Adipotide: choking off fat's food supply
Twenty-eight jabs could get rid of 27% of your belly fat.
There are so many obesity remedies that I'm don't write about many of them.
Thalidomide was demonized because of the flipper babies problem (some flipper babies...). It choked off the blood supply to growing extremities in fetuses. That same interplay makes Thalidomide effective for curing cancer. Cancer cells are freeloaders. They need your blood supply to stay alive. Thalidomide chokes off that supply. In much the same way as cancer cells, fat cells need a supply of blood (and those tasty calories). Along comes Adipotide. It's not a mood altering drug, it doesn't increase metabolism and risk some compounded health crisis; nor does it prevent the absorption of dietary fat (three guesses where the fat ends up with that strategy... ew...). Adipotide chokes off the blood supply to fat build ups; with a synthetic peptide, adipotide triggers cell death.
Each part of the body screens the peptides specific to their needs, so researchers designed a method of screening peptides and identified the peptides that bind to specific vascular cells. The blood vessels that supply fat cells work with the target protein is prohibitin, so targeting those peptides beats up on the food supply to the fat cells.
The drug is delivered through daily injections to introduce the Adipotide into the bloodstream. In trials on monkeys (why do monkeys and lab mice get all the swell cures?), the monkeys lost 11% of their total body weight, and 27% of their belly fat mass after 28 days.
The result of this is that when the supporting blood vessels have died and withered away, then fat cells are starved, reabsorbed and metabolized. Beyond weight loss, this approach subdues the secondary effects of insulin sensitivity and metabolic syndrome symptoms.
Wait-- isn't the brain a great big bunch of fatty cells? Sort of, but the monkeys in the studies remained bright and alert. They showed no signs of nausea or food avoidance though, but were unable to play the piano after the treatment. Because the dead fat cells are metabolized it appears that the principal side effects were noted in the kidneys and even that is short term. According to researchers, "The renal effect was dose-dependent, predictable and reversible."
When can we get it? If this is the real deal, we don't get this miracle pill for some time. Regardless, maybe the strategy doesn't need Adipotide. Maybe we can assault the blood supply of our fat cells and choke them off-- not through process of denying yourself and fat's food supply, but through the same approach of closing off the gates the fat needs to survive. Corral the fat and starve it out.
Do you want to try Adipotide? There is a drug trial going on but you have to have prostate cancer and be obese. Geez: what if I'm really fat but my prostate is good?
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